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05 HCO 3- (mmol/L) 13.73 �� 0.88 15.41 �� 1.09 13.55 �� 0.94 11.90 �� 0.73 12.88 �� 1.26 13.14 �� 1.74 PCO 2 (mmHg) 27.25 �� 2.18 32.06 �� 2.40 36.65 �� 5.20 39.08 �� 3.15 36.90 �� 4.02 42.11 �� 4.99 TCO 2 (mmol/L) 14.63 �� 0.92 16.50 �� 1.15 14.67 �� 1.02 13.13 �� 0.74 14.00 �� 1.36 14.33 �� 1.85 Glucose (mmol/L) 11.70 �� 1.03 12.36 �� 0.90 10.77 �� 1.10 1.08 �� 0.04*** 1.34 �� 0.12*** 1.76 �� 0.50*** Na + (mmol/L) 150.3 �� 1.7 147.9 �� 1.0 150.2 [http://en.wikipedia.org/wiki/Isotretinoin Isotretinoin] �� 0.9 155.9 �� 0.9* 154.0 �� 1.1** 150.6 �� 1.0 # K + (mmol/L) 4.088 �� 0.15 4.250 �� 0.19 4.150 �� 0.24 3.950 �� 0.30 3.589 �� 0.32 3.625 �� 0.23 Cl - (mmol/L) 121.8 �� 1.3 119.5 �� 0.8 124.0 �� 0.6 130.0 �� 1.6* 128.6 �� 1.0*** 124.3 �� 1.6 # Anion gap (mmol/L) 18.50 �� 0.53 17.25 �� 0.94 16.67 �� 0.92 18.50 �� 0.87 16.11 �� 1.11 16.25 �� 1.03 Haemoglobin (g/dl) 10.41 �� 0.54 10.93 �� 0.59 8.60 �� 0.25 9.43 �� 0.71 8.96 �� 7.33 9.53 �� 0.59 Haematocrit (%PCV) 30.63 �� 1.60 32.13 �� 1.74 25.25 �� 0.75 29.57 �� 1.17 27.88 �� 1.36 28.00 �� 1.72 View it in a separate window Abbreviations: PCO 2, partial pressure of CO 2; TCO 2, total carbon dioxide; PCV, packed cell volume; HC, HC-067047; KO, TRPV4 knockout; LPS, lipopolysaccharide Raw Data for Table 2 Blood biochemistry in healthy and endotoxaemic TRPV4 WT and KO mice. Blood gas and biochemistry were measured from venous blood samples by iSTAT point-of-care analyser in either TRPV4 [http://www.selleckchem.com/products/gdc-0068.html GDC-0068 clinical trial] KO mice, or WT mice treated i.p. Click here for additional data file.(1.3K, tgz) The effect of pharmacological TRPV4 antagonism was also assessed at an earlier time-point in pathogenesis. In contrast with the 24 h time-point, no significant difference in severity score, percentage weight loss, or core temperature was observed between vehicle- and antagonist-treated mice at 6 h post-LPS (data not shown). Blood biochemistry was similarly equivalent between treatment groups at the 6 h time-point ( Table [http://www.selleckchem.com/products/incb28060.html INCB28060 solubility dmso] 3). Table 3. Blood biochemistry in healthy and endotoxaemic WT mice treated with TRPV4 antagonist or vehicle. Blood gas and biochemistry were measured from venous blood samples by iSTAT point-of-care analyser in WT mice treated i.p. with vehicle (10% DMSO) or HC-067047 (HC), either under na?ve (24-h treatment) or endotoxaemic (LPS 12.5 mg/kg, i.v., 6 h or 24 h) conditions. Data are presented as mean �� SEM. *p