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Data collection process Data was independently extracted from reports in the form of variables according to the aim and themes of the present review as listed below. Risk of bias assessment Risk of bias (e.g., lack of information or selective reports on [http://en.wikipedia.org/wiki/MMP23B MMP23B] variables of interest) was assessed at the study level. The risks were indicated as lack of precise information of interest in each individual study that can blind the reader from particular information about the examined samples. The Cochrane Collaboration tool for assessing risk of bias [13] was used to assess bias across the studies that could affect cumulative evidence. RESULTS Study selection The search displayed 876 results from the NCBI PMC and PubMed databases and 3 results from other sources (dental-tribune.com, acta.tums.ac.ir, hindawi.com/journals). A total of 879 search results were screened. Preliminary exclusion was made by duplication and relevancy (n = 841). A total of 38 titles and abstracts were selected according to relevancy after duplication removal. Exclusion was made according to information amount regarding the selected topic (n = 11). Twenty-seven full text articles assessed for eligibility. During the eligibility stage, articles that did not meet the inclusion and exclusion criteria were filtered as follows: no minimum 6 months of follow-up (n = 6). In the end, 21 articles were included in the systematic review. Data was included for 638 patients (Figure 1). Study characteristics A total of [http://www.selleckchem.com/products/abt-199.html Venetoclax solubility dmso] 21 studies were included in this review. Ten were related to IANT, 7 to IANL and 4 to both IANT and IANL (Table 1). Table 1 Description of studies included in the review Risk of bias within studies Data supplied was checked for the following risks of bias within the selected studies: low number of patients (10 or fewer); ND examined by less than 2 methods; random selection of patients; exact post-operative outcomes not indicated for each patient. Any discrepancies or unusual patterns were checked with the study investigator. After analysing of the risk of bias (Table 2), we found that 10 authors [3,7,8,14,15,17,23,24,26,27] used a low number ([http://www.selleckchem.com/products/pci-32765.html check details] that