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Baseline characteristics for [http://www.selleckchem.com/products/BIBF1120.html learn more] stage 1 and 2 cohorts, as well as the combined cohort are shown in Table?1. No major differences were seen between both cohorts, and the mean age (56?years), male predominance (69.0%), percentage of patients with asthma (41.4%), aspirin intolerance (18.4%), and family history of NP (18.0%) were in accordance with previous reports (5, 12). As we also included patients who had previous surgery for documented NP, up to 101 (37.0%) patients had a Davos score of 0 on the day of study inclusion. Sinus CT scans were performed at the discretion of the treating surgeon and were accessible in 62 (22.7%) NP patients. As expected, Spearman��s rho correlation coefficients between the sinus CT scan and the endoscopic Davos score were 0.377 (P?=?0.003) for the right and 0.450 for the left sinus (P?=?0.0002). Overall, this indicates that our NP cohort is in accordance with previously published reports (5, 12). In the first stage (NP-1), we [http://www.selleckchem.com/products/umi-77.html UMI-77 research buy] genotyped all 10 SNPs recently reported to be associated with blood eosinophil counts (16). For none of these, the genotype distribution deviated from Hardy�CWeinberg equilibrium. Furthermore, all allele frequencies were in accordance with those observed in the HapMap CEU population. When comparing allele frequency of all 10 SNPs between NP patients and controls, the rs3939286 variant was significantly associated with NP (OR?=?1.60; 95% CI?=?1.16�C2.22; P?=?0.0041, Table?2). This association remained significant after correction for multiple testing at a preset threshold of P?[http://en.wikipedia.org/wiki/Megestrol_acetate Megestrol Acetate] and NP-2 validation cohorts further confirmed that the risk GA and AA genotypes were significantly increased in the nasal polyp cases compared with controls, with the A-allele conferring a risk for NP with an OR of 1.53 (CI: 1.21�C1.96; P?=?0.00041, Table?3). There was no significant heterogeneity between the associations in both cohorts (Cochran Q statistic for heterogeneity P?=?0.49). At the genotypic level, the rs3939286 SNP followed an additive risk effect. Indeed, compared with homozygous wild type carriers (GG), heterozygous (GA) and homozygous (AA) carriers of the A-risk allele had an increased risk of 1.55 (CI?=?1.12�C2.14; P?=?0.008) and 2.40 (CI?=?1.28�C4.49; P?=?0.006), respectively (overall P?=?0.003). As eosinophils also play an important role in asthma and allergy, and asthma and allergy were present in 41.