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Mean velocity, minimum area, and maximum area of mean pulmonary artery (MPA) were measured on phase-contrast MRI (PC-MRI). On CT images MPA diameter was obtained. We also measured the volume of fibrosis and normal lung using computer-aided system. [http://www.selleckchem.com/products/BKM-120.html see more] These parameters were correlated with mean pulmonary arterial pressure (mPAP) measured by RHC using Pearson's correlation analysis. The area under the receiver operating characteristic (ROC) curve were constructed to assess the predictive value of these parameters in the identification of PH. Results?Nineteen patients had PH at rest (mPAP more than 25?mmHg by RHC). CT measurement of MPA diameter (r?=?0.509, p?[http://www.selleckchem.com/products/nu7441.html NU7441 nmr] for suspicious PH. KOICHIRO TATSUMI, YORIKO SAKURAI, AYUMI SEKINE, RINTARO NISHIMURA, TAKAYUKI JUJO, TAKESHI KAWASAKI, TOSHIHIKO SUGIURA, SEIICHIRO SAKAO, YASUNORI KASAHARA, NOBUHIRO TANABE Department of Respirology, Graduate School of Medicine, Chiba University, Chiba, Japan Background and Aim of Study?Pulmonary arterial hypertension (PAH) associated with drugs is a well-recognized subgroup. At the 2008 WHO meeting in Dana Point, updates were made to reflect the strength of these associations as definite (aminorex, et?al.), possible (cocaine, et?al.), likely (amphetamine, et?al.) and [http://en.wikipedia.org/wiki/Oxygenase Oxygenase] unlikely (oral contraceptives, estrogen). Other than these candidates may cause drugs-associated PAH. Methods?A 38-year-old woman took the herbal medicine ��bofutsushosan�� for two weeks then stopped taking it due to general malaise and exertional dyspnea. The cause of exertional dyspnea was seeked to find. Results?After discontinuation of bofutsushosan, dyspnea continued for three months and echocardiography revealed tricuspid regurgitation pressure gradient of 40?mmHg, suspecting the existence of PH. A chest roentgenogram showed prominent hilar pulmonary artery with CTR of 51.5%. 6MWD was 486?m with lowest oxygen saturation of 89%. The perfusion scans were normal and contrast CT scans did not show pulmonary embolism. Right heart catheterization revealed elevated PAP of 64/21 with mPAP of 41, pulmonary capillary wedge pressure of 9, and a CI of 4.67, resulting in calculated PVR of 326. She was treated with oxygen and diet therapies. Her dyspnea on exertion gradually disappeared after discharge, and 8 months later she did not need oxygen. Her BNP was normalized and a chest roentgenogram revealed an improved cardiac enlargement.