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As they were normally distributed, they were assessed using one-way analysis of variance (ANOVA) (using SPSS software version 11.0) followed by the least significant difference (LSD) post-test. For the analysis of cataract development data, non-parametric tests (Kruskal-Wallis [http://en.wikipedia.org/wiki/Hsp90 HSP90] and Mann-Whitney by the Bonferroni��s post-hoc test) were used. Independent t-test by Bonferroni��s post-hoc test was used to determine the significance of the difference in blood glucose. For comparing the time course of changes in blood glucose and cataract progression in the experimental groups, repeated measure test was used. P reversed the changes of blood glucose at P[http://www.selleckchem.com/products/Temsirolimus.html http://www.selleckchem.com/products/Temsirolimus.html] of melatonin on blood glucose levels in experimental rats. Data show the average of the results of all animals in each group. The symbol ��#�� denote the significant difference from the control group and ��*�� represent ... Table 1 Effects of melatonin on HbA1c levels in experimental rats Non-fasting plasma glucose levels were significantly higher in STZ-treated rats than in normal control rats (P There was a significant difference in plasma glucose levels between untreated diabetic and diabetic rats, treated with melatonin after 4-8 weeks (independent t-test and Bonferroni��s post-hoc tests). Cataract Development The onset of cataract was seen due to hyperglycemia by slit lamp examination after 1 week of STZ injection (figure 2c). Although all lenses in group I (normal control rats) [http://www.selleckchem.com/products/Etopophos.html Etoposide manufacturer] and group IV (normal rats+MT) were clear and normal during the experiment��s period, in group II (untreated diabetic rats) 30% of the lenses had score 2, 50% had score 3, and 20% had score 4 of cataract formation and none of them were clear after 4 weeks (figure 2a). These data indicated a significant difference of the incidence of cataract in group II compared to the rats in group I (P