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?3). The levels of IL-6 and MIP-2 were increased in the BAL of mice exposed to PM10 from Newman compared to saline-exposed mice (Fig.?4). The magnitude of the increase in IL-6 at the peak of the response was the same in the 30 and 100?��g group (P?=?0.20). In contrast, the maximum response was lower in the 10?��g group compared to the other exposure groups (vs. 30?��g, P?=?0.005; vs. 100?��g, P?[http://www.selleckchem.com/products/sch-900776.html selleck screening library] 6?h timepoints, the levels of MIP-2 were increased at all three doses compared to saline-exposed mice (P? these timepoints between PM10 exposure groups. However, the increase in MIP-2 persisted in the 100?��g exposure group and exceeded those of the saline levels 12?h post-exposure (P? in the lungs. In order to achieve this, we compared cellular influx and cytokine and protein levels in the BAL of mice exposed to 100?��g of geogenic particles collected from Kalgoorlie and Newman (Fig. S1 available as supporting information online). The number of macrophages [http://www.selleckchem.com/products/AC-220.html Quizartinib manufacturer] in the BAL of mice exposed to 100?��g of particles from Kalgoorlie was higher than that of mice exposed to particles from Newman 7 days post-exposure although the magnitude of this difference was small (P?[https://en.wikipedia.org/wiki/Sitaxentan Sitaxentan] mice exposed to particles from Newman compared to both mice exposed to particles from Kalgoorlie (P??0.10 in all cases), mice exposed to particles from Newman had significantly higher levels of IL-6 in the BAL at the 12?h (P?