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The design of the trial is presented in figure 1. The CONSORT statements for non-pharmaceutical27 and pragmatic28 trials will be used to guide trial conduct and will be reported according to the [http://www.selleckchem.com/products/ch5424802.html Alectinib manufacturer] Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines as well as the TIDieR framework for intervention description.29 30 Using trial data, an Incremental Cost-Effectiveness Ratio will be calculated to assess the intervention's relative costs and benefits in terms of gain in mobility and quality of life. A qualitative substudy using a grounded theory approach with structured interviews will be conducted among a subset (n=30�C50) of intervention participants and study staff. Figure?1 Trial design. Participants and study sites Research physiotherapists employed for the trial will recruit 300 inpatients from the aged and neurological [http://www.selleckchem.com/PI3K.html PI3K inhibitor] rehabilitation wards at two metropolitan hospitals in Sydney and Adelaide, Australia; and from a metropolitan specialised brain injury unit in Sydney, Australia. We anticipate a total of 10 participants to be recruited every 3?weeks with different recruitment rates at each site due to differences in bed numbers and length of stay. All patients admitted to the study wards during the study period will be screened for eligibility in accordance with the inclusion and exclusion criteria. Those patients deemed potentially eligible will continue to be screened until they either meet eligibility or are ineligible. Patients will be eligible for recruitment if they are at least 18?years old; have reduced [http://en.wikipedia.org/wiki/Tryptophan_synthase Tryptophan synthase] mobility (Short Physical Performance Battery (SPPB) score of