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All of these were compatible with a normal distribution, except that of acetoacetate, which had also a very high variation (cv of 60%). A systematic analysis of the 1D spectra, using both presat and the CPMG TE 136?ms, was achieved by integrating all of the observed peaks and calculating the lineal correlation with some factors, e.g. the age and the fertilisation rate of the oocytes. No statistically significant correlation was found. The correlations between some important intermediaries in the energetic pathways of the follicle were analysed through integration of well-separated peaks in the CPMG spectra at TE 136?ms. The data for [http://www.selleckchem.com/products/byl719.html see more] glucose, lactate, acetate, acetoacetate, ��-hydroxybutyrate and pyruvate were divided into two age groups that were well-separated and balanced: ��25 years (group A1) and ��27 years (group A2). The correlation coefficients and probabilities of the correlations inside each group are gathered in Table 2. A negative correlation can be observed between [https://en.wikipedia.org/wiki/Pramipexole Pramipexole] glucose with ��-hydroxybutyrate, lactate, pyruvate and acetoacetate, whereas the correlation between glucose and acetate is positive. Finally, it is worth mentioning that some of these correlations between metabolites were also found when the samples were grouped by the normalised fertilisation rates (group B1: > 60%; group B2: [http://www.selleckchem.com/products/Bosutinib.html SKI-606 ic50] correspond to the group classified as the essential amino-acids which cannot be synthesised by the organism and must be incorporated in the diet. These were valine, leucine, isoleucine, phenylalanine, tyrosine, methionine, threonine, lysine, arginine and histidine. Likewise, some metabolic derivatives from the latter, such as 3-methylhistidine, and other non-protein amino acids such as creatine and taurine were also identified. Contradictory results have been reported between the amounts of amino acids (AA) in the FF and those found in plasma 32. One study 4 reported that all of the essential AAs and most of the non-essential AAs had significantly lower concentrations in FF than in plasma, with the particular exception of glutamate, which is higher (around threefold) in FF. Interestingly, L-glutamate is used in the very early stages of embryo development, and it has been suggested that it can act as a protective agent against oxidative stress 33, 34. The low concentration of AAs, relative to plasma, may reflect the utilisation of these AAs by the oocyte and/or by the follicular cells, or by selective transport through these cells. This second possibility would confirm that the follicular fluid is a selective transudate from the plasma as has been described in earlier research 1.