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The vertical distances from the gonion to the horizontal planes were set as the heights of the MnF in the mandible, according to each horizontal plane. Based on each of the five horizontal planes that pass through the MnF, the distance on each plane from the anterior ramus point to the posterior ramus point was designated the anteroposterior horizontal distance of the ramus (Table 4). The perpendicular distance from each anterior ramus point to each vertical plane was designated the horizontal distance from the anterior ramus [http://www.selleckchem.com/products/ag-221-enasidenib.html AG-221 mw] to the MnF (Fig. 3). Fig. 2 Five horizontal planes are used as reference planes for measuring the vertical height of the mandible: A. the MnF-mandibular plane; B. the MnF-occlusal plane; C. the MnF-SN/AGN p plane; D. the MnF-SN/Gn p plane; and E. the MnF-Cond/Gn p plane. Fig. 3 Five vertical planes are used as reference planes for measuring the horizontal distance from the anterior ramus to the mandibular foramen (MnF). A. the normal MnF-MnPl plane; B. the normal MnF-OccPl plane; C. the SN/AGN plane; D. the SN/Gn plane; and ... Table 4 Descriptions of the measurements performed [http://www.selleckchem.com/products/rsl3.html RSL3 mouse] in this study Analysis of the measurement values To investigate the positional relationship of the MnF in the mandible, regression analysis was used to examine the rational relationships between the vertical heights of the coronoid process, sigmoid notch, and condyle points and the vertical height of the MnF. Regression analysis [https://en.wikipedia.org/wiki/Succimer Succimer] was also used to determine the rational relationship between the anteroposterior horizontal distance of the ramus from each of the five horizontal planes passing through the MnF and the horizontal distance from the anterior ramus point to the MnF. The study data were analyzed with IBM SPSS Statistics version 21 (IBM Corp., Armonk, NY, USA), and statistical significance was established at p