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3235) and Hainan CDC. Written informed consent was obtained from all study participants before their enrolment into the study. Table 1 presents the descriptive statistics of the study participants. Results of a two-way analysis of variance (ANOVA) test indicated that CRP concentration (P?=?0.025), overall QOL (P?=?0.015), and psychological domain (P?=?0.002) differed by region. Sex differences were found in EBV antibody titer (higher in females; p?[http://www.selleckchem.com/products/fg-4592.html www.selleckchem.com/products/fg-4592.html] 0.56 (the psychological domain and the environment domain) (data not shown). Table 2 shows the results of the regression analysis. After adjusting for the effects of age, sex, region and CRP concentration, EBV antibody titer was negatively associated with the physical domain (Model 3, P?=?0.044) and psychological domain (Model 4, P?=?0.039) of QOL. In Models 1, 2, 4, and 5, however, there was no association between EBV antibody titer and the QOL subscales. The variance inflation factors (VIF) for each model showed no evidence of multicollinearity. This is the first study to examine the association between EBV antibody titer and validated QOL scores. EBV antibody titer was shown to be negatively associated with the physical and psychological QOL domain scores. EBV antibody titer has been used as a biomarker of [https://en.wikipedia.org/wiki/PTPRJ PTPRJ] psychological stress on the basis of biological evidence which suggests that more of it generally links psychological stress and EBV activity (Cacioppo et al., 2002; McDade et al., 2000a) and inductively as a result of empirical findings showing elevated levels of EBV antibody titer among people experiencing psychological stress (Esterling et al., 1992; Glaser et al., 1987; Kiecolt-Glaser et al., 1987a; Kiecolt-Glaser et al., 1987b; Panter-Brick et al., 2008). Against this backdrop the results from the present study accord with those from previous studies in other locations which have demonstrated an association between EBV antibody titer and indicators of psychological stress or well-being [http://www.selleckchem.com/products/scr7.html SCR7 in vivo] (Glaser and Kiecolt-Glaser, 2005). Our research in Hainan Island, which has been ongoing, since 2000, has indicated that the economic and nutritional status of the local people in rural communities has improved significantly in recent years. More people have started to earn money by introducing cash crops or engaging in migratory work and their consumption of meat and fish has increased. Moreover, infrastructural elements such as electricity, piped water supply, telephone services, and traffic roads have all been introduced to the island's communities in the past 15 years.