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Table?1 shows the description of subjects with or without virological control at 24?weeks after RAL initiation. The GSS of RAL companion drugs, i.e. not including RAL, was analysed through a 0.25-step stratification using AntiRetroScan in 105 subjects with available resistance data (RT+PRO) at RAL initiation. The majority of the individuals had a GSS of 1 (25.7%); however, 49.5% of the subjects had a GSS ��1. The most frequent protease [http://www.selleckchem.com/products/pci-32765.html selleck compound] inhibitor was darunavir, few enfuvirtide treatments were observed, and etravirine was present in around 20% of subjects without a difference in the virological outcome. The median number of PRO and RT mutations at failure was lower than at baseline: 8 (IQR 2�C15) versus 11 (IQR 5�C16) and 5 (IQR 2�C12) versus 8 (IQR 3�C11), respectively. As expected, week-24 non-responders had a higher number of mutations at failure compared with responders, both in PRO (12; IQR 5�C19, versus 7; IQR 2�C13) and RT (9; IQR 3�C19, versus 4; IQR 2�C10), without showing any statistical significance. Of the 24 RAL-failing subjects with available IN genotype, [http://en.wikipedia.org/wiki/TRIB1 TRIB1] 12 (50,0%) did not show any mutation or just had natural IN polymorphisms (H51Y, V72I, G140S, K156N, E157Q and V165I). Conversely, resistance mutations associated with RAL failure were detected in the other 12 subjects: five Q148H?+?G140S pathway, four N155H pathway, two Y143C/R pathway, and one subject with mixed Y143R?+?N155H. Kaplan�CMeier estimation showed a 74.3% virological response after initiating a RAL-containing regimen in the entire cohort. GSS >1.5 had the highest effect with approximately 85% of a virological response. In parallel, [http://www.selleckchem.com/products/MK-2206.html MK-2206 order] weighted-GSS >1.5 showed 82% of a virological response compared with other weighted-GSS strata (Fig.?1a,b). Univariate analysis (Table?2) revealed an increased probability of virological response for older subjects: the OR for each extra-year was 1.09, 95% CI 1.02�C1.77 (p 0.016) counts, whereas nadir CD4, baseline CD4 counts, peak HIV-1 RNA, and baseline HIV-1 RNA were not associated with virological suppression. Each extra unit of GSS (p 0.05, OR 2.62; 95% CI 1.00�C6.87) was found to be a factor associated with response. Weighted-GSS had borderline statistical significance (p 0.063, OR 2.04; 95% CI 0.96�C4.33). When stratifying for different cut-offs (