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In addition, diabetes mellitus was also included [http://www.selleckchem.com/products/ly2109761.html LY2109761 cell line] in the host criteria. Diagnosis by histology was made if large, non-septate hyphae were reported. The sites of infection were classified as recently described by Roden et?al. [4]. Mortality was assessed as all-cause mortality during the course of zygomycosis. Statistical analyses were conducted using spss v.16. Differences between the qualitative variables in two or more groups were analysed by a chi-square test. A two-sided p value of [http://en.wikipedia.org/wiki/MAPK MAPK] statistically significant relationship was shown (p?[http://www.selleckchem.com/products/epz-5676.html EPZ5676] than 14?years and three were ��1?year old. The patients�� underlying conditions are listed in Table?1. In the month prior to diagnosis of zygomycosis, 106 (46%) patients received corticosteroids and 101 (44%) received other immunosuppressive medications (cyclosporine, mycophenolate-mofetil, tacrolimus, everolimus, methotrexate, cyclophosphamide, daunorubicin, vincristin, cytarabin, chlorambucil, fludarabine or novantrone). One hundred and ten patients (48%) received antifungals in the same period: fluconazole (19%), itraconazole (3%) and posaconazole (1%) as prophylaxis, and voriconazole (19%), caspofungin (13%) and amphotericin B (13%) as empirical treatment. Eight patients with haematological malignancies also had diabetes mellitus, secondary to steroid use in most cases, while in one case, the patient had acute lymphoblastic leukaemia and AIDS. Diabetes was the sole predisposing factor in 21 (9%) patients. In another 18 (8%), diabetes was combined with other underlying conditions, such as malignancy or trauma.

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