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014, data not shown). Fig. 2 shows the prevalence of metabolic components, including hypertriglyceridemia, low HDL-C, and hypertension in MetS as defined by the KOSSO criteria and our criteria. In both sexes, the number of subjects with each metabolic risk factor increased significantly when our criteria were applied compared to the KOSSO criteria. Fig. 1 Receiver operating characteristic analysis of waist circumference (WC) to detect the presence of two or more metabolic components, visceral obesity, and insulin resistance (IR) in (A) men and (B) women with type 2 diabetes. The higher the GDC-0449 cell line area under the ... Fig. 2 Differences in the prevalence of metabolic components according to Korean Society for the Study of Obesity (KOSSO) criteria and our criteria in (A) men and (B) women with type 2 diabetes. Compared to metabolic syndrome (MetS) as defined by the KOSSO criteria, ... Table 3 Differences in insulin sensitivity (Kitt), VFT, and CIMT according to the presence of metabolic syndrome defined by KOSSO criteria and our criteria in subjects with type 2 diabetes DISCUSSION Obesity and MetS are now common in Asia, and Korea is no exception [24]. According to data from the 2007 to 2008 Korea National Health and Nutrition Examination Surveys, which included more than 7,000 participants click here aged 19 to 65 years, the prevalence of MetS is 15.8% in men and 11.6% in women [25]. Another study reported that MetS accounts for 77.9% of type 2 diabetes cases in Korea [26]. Diabetic patients with MetS have a higher prevalence of coronary heart disease than those without MetS [4]. Type 2 diabetes and MetS are closely connected in terms of IR, which has been thought to play a central role in the development of MetS [5]. IR is also associated with obesity [27], but not all obese people exhibit features of IR. Some investigators have demonstrated metabolic disturbances in metabolically obese normal-weight (MONW) [28] or metabolically healthy obese (MHO) individuals [29]; the MONW-like phenotype showed an increased Quinapyramine risk for incident diabetes or CVD, whereas the MHO-like phenotype did not confer a markedly increased risk [30]. This suggests that IR and body fat distribution in each individual play key roles in determining risk in regards to MetS. However, neither the NCEP-ATP III nor IDF criteria include factors that directly reflect IR [12]. Instead, central obesity, as assessed by WC cutoff values, has been a criterion for diagnosing MetS. According to our previous study [31], mean Kitt value was 2.03��0.96 in Korean T2DM patients. Moreover, when classified according to insulin sensitivity, patients with no IR had HbA1c of 7.7%��1.4%, while HbA1c of patients with IR was 8.5%��1.9% (P