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10 14 15 Although radiation therapy could be helpful, it has its own acute and late side effects. In this patient the mass was just posterior to the right breast and anterior to the right lung, the most important organs at risk of side effects especially at the late phase. Since the volume of the lung receiving high radiation dose is not significant and mean total lung dose is surely less than 20 Gy the lung toxicity is acceptable. Radiation therapy of the breast of young women, however is always of great concern. The most important issue is the risk of second cancers, carcinoma and sarcoma. Most of our knowledge about radiation-induced breast carcinoma in young girls revolves http://www.selleckchem.com/products/bardoxolone-methyl.html around studies on survivors of Hodgkin's lymphoma receiving radiation with various fields and doses with and without chemotherapy. In a study performed by the German Hodgkin's Lymphoma Study Group ?breast cancer was seen in 13 patients from 5367 treated patients. Sixty-two per cent of them were between 16 and 34?years at diagnosis/treatment of the Hodgkin's disease.16 In another study carried out by De Bruin et al among 1122 women, 5-year survivors treated for Hodgkin's disease before the age of 51, after a median follow-up of 17.8?years, 120 women developed breast cancer; indicating an absolute excess risk of 57/10?000 patients/year. The overall cumulative incidence 30?years after treatment was 19% (95% CI 16% to �C23%); while for those RVX-208 treated before the age 21?years, it was 26% (95% CI 19% to high throughput screening 33%). The relative risk remained high after prolonged follow-up (>30?years posttreatment: standardised incidence ratio, 9.5; 95% CI 4.9 to 16.6). They concluded reduction in radiation volume appeared to decrease the risk of breast cancer after the Hodgkin's disease. Furthermore, women with ��20?years of intact ovarian function after radiotherapy at young ages (