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It allowed successful validation of a low-volume bioanalytical HPLC-MS/MS method according the FDA and EMA bioanalytical guidelines. The applicability of the high-throughput approach was proven by a clinical study in 24 volunteers. Acknowledgment The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under Grant Agreement no. 602295 (LENA). Conflict of Interests There is no conflict of interests regarding the publication of this paper.""When the Deepwater Horizon oil rig exploded off the northern coast check details of the Gulf of Mexico on April 20, 2010, millions of barrels of crude oil were released into the gulf before the well was capped, and later sealed, almost six months later. Fragile ecosystems, air and water quality, food supplies, human health, and economies in and around the Gulf of Mexico are still being impacted by this spill [1]. Without effective monitoring of food and water quality after such spills, fisheries could remain closed unnecessarily or products from unmonitored fisheries may enter the general food supply, leading to potential endangerment of public health. Nine PAHs were initially selected as markers for contamination in seafood harvested in and around potentially impacted areas [2]. Regulatory limits and established safe levels of exposure for each of these analytes are summarized in Table 1. Table 1 United States PAH regulatory limits for reopening impacted areas. The National Oceanic and Atmospheric Administration E-64 is responsible for closing and opening Federal waters for seafood harvest. The NOAA Office of Response and Restoration (OR&R) publication entitled Managing Seafood Safety after an Oil Spill [3] and input from NOAA, the Food and Drug Administration, the Environmental Protection Agency, and several state authorities were used to establish criteria for analytically screening seafood selleck compound for oil contamination as part of the Deepwater Horizon explosion. NOAA currently recommends using NOAA Method NMFS-NWFSC-59 2004 [4] as the preferred method for quantifying polycyclic aromatic hydrocarbons (PAHs) in seafood harvested from potentially oil-impacted areas. This gas chromatography/mass spectrometry (GC/MS) method recommends running batches of only 12 to 14 samples where assay preparation, sample preparation, and extensive sample cleanup require multiple days of work to complete. Additionally, size-exclusion high-performance liquid chromatography is completed prior to GC/MS analysis for further sample cleanup. Lastly, the GC/MS method is almost an hour long for each sample [4]. All of these steps result in a low-throughput method. Hence, there is concern that the NOAA 2004 method may not have the throughput capacity necessary during an emergency response.