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CON, UVB-p21+ vs. p21+, UVB-p21�C vs. p21�C, pOxacillin Figure 3B). p21��s effect on apoptosis rates in HaCaT keratinocytes In non-irradiated HaCaT keratinocytes, p21 dysregulation (i.e., both p21 overexpression and p21 silencing) significantly increased apoptosis rates (p21+ vs. CON, p21�C vs. CON, pBuparlisib clinical trial cells was significant upregulated compared to UVB-CON cells (UVB-p21�C vs. UVB-CON, pIPI-145 datasheet p21�C, p>0.05; Figure 5). Proliferation of UVB-p21+ cells was more obviously suppressed compared to UVB-CON cells (UVB-p21+ vs. UVB-CON, p