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3%), 16 (45.7%), and 7 (20%) patients, respectively. A dose of 30?mg/m2 was selleck chemicals llc administered to 19 patients, and 40?mg/m2 was administered to 16 patients. The mean plasma concentrations of AMR-OH on day 4 at a dose of 30?mg/m2 and 40?mg/m2 were 11.02?��?3.83 and 16.18?��?6.17?ng/ml, respectively (p?=?0.005). In patients with AMR at a dose of 40?mg/m2, the plasma concentrations of AMR-OH on day 4 exhibited a tendency toward a relationship with NQO1 genotypes with values of C/C 20.5?��?5.89, C/T 15.9?��?5.43, and T/T 11.2?��?4.47?ng/ml (p?=?0.066). The C/C was related to decrease changes in WBC, hemoglobin, and platelet counts (p?=?0.01, p?=?0.03, and p?=?0.0005, respectively). No significant correlations were observed between NQO1 genotypes and clinical outcomes at a dose of 30?mg/m2. Conclusions?NQO1 C609T polymorphism had a tendency of correlation with the plasma concentrations of AMR-OH, and thereby had significant correlations with hematologic toxicities. NQO1 genotype appears to be the candidate biomarker of hematological toxicities of AMR treatment at a dose of 40?mg/m2. ATSUSHI MITSUHASHI1, HISATSUGU GOTO1, TAKUYA KURAMOTO1, SHO TABATA1, SAWAKA YUKISHIGE1, MASAKI HANIBUCHI1, SOJI KAKIUCHI1, ATSURO SAIJO1, YOSHINORI AONO1, HISANORI UEHARA2, SEIJI YANO3, JULIE G LEDFORD4, SABURO SONE1, YASUHIKO NISHIOKA1 1Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan, 2Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University Selleck LDK378 of Tokushima Graduate School, Tokushima, Japan, 3Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan, 4Division of Pulmonary, Allergy & Critical Care, Duke University Medical Center, Durham, USA Background and Aim of Study?Surfactant protein A (SP-A) is a large multimeric protein found in the lungs. In addition to its immunoregulatory function in infectious respiratory diseases, SP-A is also used as a marker of lung adenocarcinoma. Despite the finding Quetiapine that SP-A expression level in cancer cells had the relationship with patient prognosis, the function of SP-A in lung cancer progression is still unknown. The purpose of this study is to investigate the role of SP-A in lung cancer progression and metastasis using mouse model. Methods?Human SP-A gene was introduced into human lung adenocarcinoma cell line PC14PE6 (PC14PE6/SP-A). We intravenously inoculated PC14PE6/SP-A into nude mice and examined the effect of SP-A on tumor lung metastasis. Results?PC14PE6/SP-A cells produced significantly fewer lung metastatic colonies and pleural effusion compared to vector transfected cells in vivo. Immunohistochemical analysis showed that the number of CD68-positive tumor-associated macrophages (TAMs) was increased in the lung metastatic colonies produced by PC14PE6/SP-A cells.
