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Hence, simplification of the ABCD (D1, D2) classification is proposed: Group 1: the nonmethylated, most often nonhalogenated molecules (groups A and D2, and budesonide); Group 2: the halogenated molecules with a C16/C17 cis ketal/diol structure (group B or the acetonide group); Group 3: the halogenated and C16-methylated molecules (groups C and D1). I (MB) thank the Fondation Saint-Luc of the Universit�� Catholique de Louvain (Cliniques Universitaires Saint-Luc) and the Groupe d��Etude et de Recherche en Dermato-Allergologie (GERDA) for supporting this research. None. Data S1. Chemical structure of hydrocortisone with the conventional numbering of carbon atoms. Data S2. Corticosteroid series, along with test concentrations and vehicles. RSL3 in vivo Data S3. Modelling of corticosteroid molecules with the Sybyl Molecular Modelling Suite using MMFF94 forcefield and alignment Succimer on their common steroid skeleton. Data S4. Steric/electrostatic fields calculation with the aligned structure inserted in a Cartesian grid. ""Although atopic sensitization is one of the strongest risk factors for asthma, its relationship with asthma is poorly understood. We hypothesize that ��atopy�� encompasses multiple sub-phenotypes that relate to asthma in different ways. In two population-based birth cohorts (Manchester and Isle of Wight �C IoW), we used a machine learning approach to independently cluster children into different classes of atopic sensitization in an unsupervised manner, based on skin prick and sIgE tests taken throughout childhood and adolescence. We examined the qualitative cluster properties and their relationship to asthma and lung function. A five-class solution best described the data in both cohorts, with striking similarity between the classes across the two populations. Compared with nonsensitized class, children in the class with sensitivity to a wide variety of allergens (~1/3 of children atopic by conventional definition) were much more likely to have asthma (aOR [95% CI0; 20.1 [10.9�C40.2] in Manchester and 11.9 [7.3�C19.4] in IoW). The relationship between asthma and conventional atopy was AG-221 datasheet much weaker (5.5 [3.4�C8.8] in Manchester and 5.8 [4.1�C8.3] in IoW). In both cohorts, children in this class had significantly poorer lung function (FEV1/FVC lower by 4.4% in Manchester and 2.6% in IoW; P?