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5?mg/L or >1.5?mg/L, respectively. The main outcome measure was 30-day all-cause mortality from the date of the first positive (index) blood culture. We also analysed Enzalutamide 30-day attributable mortality as defined by Lodise et?al. [3]. Extensive clinical data were collected retrospectively using chart review: heart disease (including ischaemic heart disease, cardiac failure, arrhythmia requiring insertion of permanent pacemaker or implantable cardioverter-defibrillator), end-stage kidney disease, receipt of haemodialysis, diabetes mellitus, dementia, chronic liver disease, malignancy (haematological or solid organ), transplantation (haematological or solid organ), receipt of chemotherapy, immunosuppression or corticosteroids (with an equivalent daily dose of ��20?mg prednisone), human immunodeficiency virus infection and active injecting drug use were assessed as individual comorbidities. We assessed comorbidity burden using the Charlson Comorbidity Index (CCI) [4] and presence of ��Do Not Resuscitate�� (DNR) orders. Disease severity at onset of SAB was measured using intensive care unit (ICU) -validated scores: Acute Physiology And Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score (SAPS) II and the Pitt bacteraemia score [5], a bacteraemia-validated method. Other data obtained included ICU admission and renal function at SAB onset. For data analysis, dichotomous variables for CCI and disease severity scores were also created using values associated with inferior outcomes in the published literature Venetoclax molecular weight (APACHE II ��18 [6], SAPS II >45 [7], CCI ��3 [4], Pitt bacteraemia score ��4 [8]). The index blood culture isolate from each patient was stored at ?80��C and underwent detailed microbiological testing as previously described [1]. Briefly, this included vancomycin MIC using broth microdilution [9] and Etest? (bioM��rieux, Marcy l'Etoile, France) methodologies, and screening for vancomycin heteroresistance was performed using the Glycopeptide Resistance Detection Etest? (bioM��rieux, Marcy l'Etoile, France). The chi-square test or Fisher exact test was used to compare categorical variables, and the Student's t-test or Mann�CWhitney U test was used for continuous variables. Potentially significant variables on univariable analysis (p?Histone demethylase considered a priori for inclusion in a multivariable logistic regression model. Pairwise correlation coefficients were examined between variables that were potentially related before inclusion in our multivariable model to avoid collinearity. Stepwise backward elimination was performed and variables with p?
