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, J Urol 182: 2072�C8, 2009], 25% to 84% [Hoebeke et al., J Urol 168: 2605�C8, 2002; Lord��lo et al., J Urol 182: 2900�C4, 2009], 13% to 84% [Malm-Buatsi et al., Urology 70: 980�C3, 2007; Lord��lo et al., J Urol this website 184: 683�C9, 2010], respectively. For sacral transcutaneous ENS recurrence ranged from 10% to 25%. Apart from the sacral implantation studies, any reported side effects were mild and transitory. The literature in the area of interest is sparse. Parasacral TENS has been shown to be more effective than sham in randomized trials in treating OAB. This deserves further research to elucidate the optimal parameters and the children for whom it is most useful. Neurourol. Urodynam. Neurourol. Urodynam. 30: 1429�C1436, 2011. ? 2011 Wiley Periodicals, Inc. ""It is becoming increasingly clear that a variety of metabolic, cardiovascular, and endocrine factors contribute to male pelvic health. In particular, a growing body of evidence suggests a relationship between lower urinary tract symptoms, benign prostatic hyperplasia, overactive bladder, erectile dysfunction, and the metabolic syndrome. This article explores these relationships, focusing on the role of the autonomic nervous system and hyperinsulinemia, together with their implications for urological practice. Neurourol. Urodynam. 29:1360�C1364, 2010. ? 2010 Wiley-Liss, Inc. ""Recent studies have showed that interstitial cells (ICs) are widely distributed in the genitourinary tract and have suggested their involvement in spontaneous electrical activity and muscle contraction. Nitric oxide (NO) is thought to play a role in bladder overactivity related with bladder outlet obstruction (BOO). The purposes of this study were to investigate the effect buy Ribociclib of bladder overactivity induced by BOO on ICs and nitric oxide synthase (NOS) isoforms in rat urinary bladder. Female Sprague-Dawley rats (230�C240?g, n?=?40) were divided into two groups: control (group Con, n?=?20) and partial BOO (group BOO, n?=?20). After 4 weeks, urodynamic studies measuring contraction interval and contraction pressure were done. The cellular localization of cKit immunoreactive ICs and the expression of endothelial NOS (eNOS) and neuronal NOS (nNOS) were determined by Western blot and immunohistochemistry in the rat urinary bladder. Filling cystometry studies demonstrated a reduced interval between voiding contractions and an Thalidomide increased voiding pressure in BOO bladders. The contraction interval time (2.9?��?0.35?min) was significantly decreased in the BOO group compared to the control (6.1?��?0.05; P?