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MATERIALS AND METHODS This was a randomized, investigator-blind, prospective comparative study. From August 2012 through May 2013, we enrolled 174 patients who visited the Ewha Womans University Mokdong Hospital. FG-4592 cell line Eligible patients were aged 18 years or older and scheduled to be examined by esophagogastroduodenoscopy. Patients with a history of upper GI surgery, GI bleeding, pregnancy, or contraindications for anticholinergic agents (glaucoma, myasthenia gravis, and urinary obstruction) were excluded from the study. Written informed consent was obtained from all subjects before enrollment. This study was approved by the Ewha Womans University's Ethics Committee. Patients were randomized into two groups according to the following medications administered prior to upper endoscopy: oral phloroglucin (group A) and cimetropium bromide (group B). All endoscopic procedures were performed by a single experienced endoscopists who was blinded to the patients' group assignments. We evaluated total procedure times (from insertion to removal), total number of peristalsis events (stomach and duodenal motility numbers, counted at the antrum and duodenal second portion for 30 seconds each), and patient responses to questionnaires assessing tolerance and adverse events during the procedure (mouth dryness, nausea, vomiting, dizziness, Quetiapine headache, and abdominal pain). The degree of peristalsis was assessed using visibility scores (range, 0 to 2) at the antrum and duodenal second portion (0, no peristalsis; 1, slight peristalsis but no obscured visibility; 2, severe peristalsis with obscured visibility). Statistical analysis Demographic characteristics and visibility scores were assessed using the chi-square test and Student t-test. A p-value patients enrolled in the study, two were excluded because of severe duodenal stenosis. The remaining 172 patients were randomized into two groups according to medication administered KRX-0401 datasheet prior to upper endoscopy, namely oral phloroglucin (group A, n=86) or cimetropium bromide (group B, n=86). The demographic and other baseline characteristics of included patients are shown in Table 1. There was no statistically significant difference between the two groups regarding age, sex, medical history (with the exception of thyroid disease), and the proportion of patients taking sedatives for endoscopy. Table 1 Demographic Characteristics of Patients in Each Group The incidence and degree of peristalsis in each group is presented in Table 2. A significantly higher number of gastric peristalsis events was seen in group A (0.49��0.85 vs. 0.08��0.28, p