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This led to a predominance of taxane-based adjuvant trials only Oxalosuccinic acid in patients with lymph-node positive cancer. These trials were commenced prior to the recognition of the importance of other biological factors such as histological grade and hormone receptor status in determining prognosis. A meta-analysis of taxane-based adjuvant chemotherapy trials reported by Ferguson et?al.32 found that when all taxane-based trials were included there was a significant benefit in terms of overall survival for the inclusion of a taxane (HR 0.81 (95% confidence interval [CI], 0.75�C0.88; P?selleck chemicals prognosis than many patients with lymph node-positive disease, yet their funded chemotherapy options in Australia have been previously restricted. Similarly, patients with HER2-negative node-positive disease have had funded access to taxanes restricted to use in combination regimens that mandated the inclusion of anthracyclines. With the increasing MI-773 evidence supporting the use of standard taxane-based regimens in patients with node-negative disease, the wider availability of TC via the PBS provides an alternative to anthracycline regimens in patients with high-risk node-negative disease and those with pre-existing cardiac disease. Despite the results from the randomized controlled trials, there are limitations to the evidence supporting the use of non-anthracycline regimens. With respect to the TCH regimen, the data have been presented only in abstract form, albeit on three separate occasions (San Antonio Breast Cancer Symposium 2005, 2006, and 2009). A full paper has yet to be published, meaning that the full data set has not been subjected to peer review. The TC regimen has so far been studied in only 1 large trial, and although the data have been published twice,26,30 further data from comparable trials would strengthen the argument for non-anthracycline regimens. Currently accruing in the USA is the so-called TIC-TAC-TOE trial (ClinicalTrials.gov Identifier: NCT00887536) which initially was planned to compare six cycles of TC with six cycles of TAC. Accrual was to be 2000 patients.
