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9%. For all lipid measurements, only previously unthawed serum samples were used. Levels of total cholesterol, HDL, LDL and triglycerides were measured by the general laboratory of Krankenanstalten Dr. Dostal using enzymatic methods. For quantification of HDL subfractions, the Quantimetrix HDL Lipoprint System? (Quantimetrix Corporation, Redondo Beach, CA, USA) was used according to manufacturer's instructions as previously described [30]. Briefly, HDL subfraction separation and quantification with this system is based upon high resolution polyacrylamide gel electrophoresis and divides HDL into 10 subfractions. Subfraction 1�C3 represent large HDL particles, subset 4�C7 the intermediate HDL subtype while subsets 8�C10 represent small HDL particles [31]. Categorical variables Docetaxel manufacturer selleck screening library are expressed as counts or percentages and were compared by the ��2 or by Fisher's exact test where appropriate. Continuous variables are given as mean?��?standard deviation. Parametric data was compared using ANOVA, while skewed data (assessed by the Kolmogorov�CSmirnov test) was compared by ANOVA after log-transformation. Correlations were calculated using Pearson's correlation coefficient. Linear regression models were calculated for all three monocyte subsets, respectively. Clinical characteristics, statin treatment or lipid parameters were added to the models when they were associated with monocyte subsets or small HDL levels by a p-value tiospirone statistically significant. All statistical analyses were performed with the Predictive Analysis SoftWare PASW Statistics 18.0 (IBM, Armonk, NY, USA). Ninety patients with angiographically proven stable coronary artery disease were enrolled in this study. Table?1 shows the clinical characteristics. Mean age was 64.1?��?10.0 years, 72 patients (80%) were male and 21 (23%) were smokers. 25 (28%) had single vessel disease, 36 (40%) had two diseased coronary arteries and 29 patients (32%) had triple vessel disease. 31% of patients were on a high-dose statin, 52% of patients received low-dose statin treatment while 17% of patients were not treated with statins. Small HDL levels were not associated with total HDL levels but showed significant correlations with triglycerides, VLDL, LDL and total cholesterol levels (Table?2). In contrast, large HDL that was inversely correlated with small HDL, highly correlated with total HDL and correlated inversely with VLDL and triglyceride levels. Intermediate HDL correlated with large HDL but showed in addition an association with LDL and VLDL. In contrast to small HDL, intermediate HDL did not correlate with triglycerides. Intermediate HDL (28.8?��?7.1 vs. 23.7?��?5.8?mg/dL; p?=?0.002) and large HDL (19.3?��?11.1 vs. 10.7?��?5.7?mg/dL; p?=?0.