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The other three couples involved only two or three care units each. The data showed under-dispersed Poisson distribution. The negative binomial regression was thus used. Moving in the year was not associated with the incidence of P. aeruginosa. Thus, this variable was removed from multivariate analyses. The results of the GEE model showed a lower incidence for GH than for NewB: IRR 0.69, p=0.039 (Table 1 (Tab. 1)). An overall effect of the building was observed (pCasein kinase 2 with and without intensive care units (sensitivity analysis) Discussion All cases of P. aeruginosa occurring during more than 9 years were included. This long-term study concerned 29 units cumulating 2,759 P. aeruginosa cases during 1,958,985 patient-days. The results of this study are not clearly in favour of our assumption that moving to a new building would lead to less exposure of patients to water contamination, and would thus cause a decrease in cases. A momentary disruption of the ward organisation at the time of the move could have increased the risk of HAI. However, no association was found with this variable. The probable longer-term reorganisation of wards after moving, with a lower caregiver-to-patient ratio, could also balance out the benefit of new water systems. Samples from the selleck kinase inhibitor old buildings showed contamination. As a corrective measure, several water outlets had filters fitted, thus eliminating exposure to contaminated water. Conversely, in the NewB, as few samples had been taken because the move was recent, filters had been fitted at very few outlets. In addition, in the NewB, there are more water outlets so they were probably less frequently used than was the case in old buildings. This can lead to the constitution of a biofilm [16]. However, samples were mostly negative. Finally, several apparatus may have been reconnected to the new water supply (water fountains, dialysis find more equipment, endoscope washers��). These could favour the contamination of the new water system. This study had some limitations. Firstly, the cases were assigned to the care unit that prescribed the sample, which was generally but not necessarily the care unit where the patient was located. Moreover, though we required a minimum of 48 hours of hospitalisation before the first positive sample to take account of that sample, the time the patient spent in the unit before the positive sample was not taken into account. However, patients rarely moved from one unit to another. Secondly, several care units moved in 2014. These recent moves led to a small number of patient-days for the NewB and thus lower power.