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A case-controlled study was selleck products therefore designed to determine the frequency of HLA-B*1502 in SCARs patients at a large teaching hospital in Hanoi-Bach Mai Hospital, Vietnam. MATERIALS AND METHODS Subjects The study was conducted at the Center of Allergology and Clinical Immunology, Bach Mai Hospital between 2011 and 2013. There were a total of 63 participants divided into two groups (38 patients with SCARs and 25 controls). A survey instrument, focused on the history of the presenting illness, ethnicity, family history, medication usage, past medical history, any history of drug allergy and rashes, review of symptoms and physical examination, was developed. Severity-of-illness score for toxic epidermal necrolysis (SCORTEN) was applied for severity assessment [23]. SCORTEN has been defined as seven criteria including age (>40 years), heart rate (>120 beats/min), presence of malignancy, skin detachment (>10% body surface area [BSA]), serum urea level (>10 mmol/L), serum bicarbonate level (14 mmol/L). Maximum severity score is 7. All patients had their diagnosis of CBZ-induced SJS/TENS/DRESS confirmed by either a dermatologist or an allergologist based on the clinical morphology of the ""rash"" according to Roujeau [24]. Medication-induced rash was considered to have occurred when indicated by the evaluation above, when the symptoms commenced within the first 2 months of exposure to the drug and when those symptoms resolved upon withdrawal of the drug. Challenge, either blind or open, is unethical TRIB1 and potentially fatal. RegiSCAR inclusion and exclusion criteria were applied in this study as below. As all patients seen with drug-induced SCARs were taking CBZ. Inclusion criteria For SJS/TEN CBZ was the culprit medication (established by ruling out comedication within 2 months). Inpatients. Widespread exanthema and more MK-2206 nmr than 1% BSA skin detachment; blister formation, not acral involvement alone, with or without mucous membrane erosions. SJS was defined as less than 10% of BSA skin detachment, ulceration in more than two natural cavities. TEN was defined as more than 30% of BSA skin detachment and/or the presence of Nikolsky's sign. For DRESS CBZ was the culprit medication (established by ruling out comedication within 2 months. Acute onset of skin rash with fever over 38��. Enlarged lymph nodes. Involvement of at least one internal organ. Eosinophilia >10% or >700/?L, atypical lymphocytes, lymphopenia