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Body weights of the rats in the TG group were reduced in weeks 1�C2. The body weights of the rats in the sham group increased gradually throughout the study period, whereas those in the TG groups remained nearly constant after week 8. No significant differences in the body weights were observed among the three TG groups. Figure 1. Changes in body weight of the rats 22 weeks after surgery in each experimental group. The body weights of the rats in the sham group increased gradually throughout the study period, whereas those in the TG groups remained nearly constant after week 8. ... Bone mineral density (BMD) of the femur Twenty-two weeks after TG, the rate of the calcified Anticancer Compound Library bone area in the traced are in the TG control group (50.0��8.1%) was lower than that in the sham group (69.0��5.6%) (Fig. 2). The rates in the TG plus rabeprazole (56.5��7.5%) and TG plus minodronic acid (59.0��6.0%) groups were significantly higher than that in the TG control group (PCeramidase to that of minodronic acid (Fig. 2). Figure 2. Bone mineral density of the femoral bone. Twenty-two weeks after surgery, the rate of the calcified bone area in the traced area in the TG control group (50.0��8.1%) was lower than that in the sham group (69.0��5.6%). The rates in the TG ... Bone strength Femoral bending strength was markedly decreased in the TG control group (152.34��24.01 N?m) compared with that in the sham group (251.99��23.14 N?m). This effect was significantly ameliorated and also counteracted with minodronic acid treatment (190.50��26.95 N?m), but not by the rabeprazole treatment (151.67��22.41 N?m) (Fig. 3). Figure 3. Femoral bending strength in the different groups. Femoral bending strength was markedly decreased in the TG control group (152.34��24.01 N?m) compared with that in the sham group (251.99��23.14 N?m; *Pthis website Compared with that in the sham group, the serum calcium levels were reduced in rats with TG, while the serum phosphorus levels remained unchanged by TG or by the administration of either minodronic acid or rabeprazole. Minodronic acid significantly decreased the serum calcium level compared with the level in the TG control group (P
