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These suggest that this gene participated in COPD development, but its role in cigarette induced airway inflammation remains unclear. Our aim is to explore the role of HHIP gene in cigarette induced airway inflammation. selleckchem Methods?We devided human alveolar epithelial pulmonary cells into two groups: control and HHIP gene silent cells. The later were constructed with siRNA technic. The two groups were stimulated with cigarette smoking extractwith different concentration for different time, then we compared mRNA and protein expression level of IL6, IL8, ICAM before and after using PCR and western blot. Results?After cigatette stimulation for 24?h, the mRNA and protein expression level of IL6, IL8, ICAM, increased significantly in HHIP gene silent A549 group compared with control A549. Conclusion?HHIP gene plays an important role in regulation of cigaretteinduced airway inflammatory mediators levels. Deficient of the gene may lead to development of COPD. Further gene therapy needs to be investigated. SAMEERA ANSARI, HASSAN HOSSEINZADEH, SARAH DENNIS, NICHOLAS ZWAR School of Public Health & Community Medicine, The University of New South Wales, Sydney, Australia Background?A major cause of morbidity and mortality worldwide, COPD often occurs in the presence of multiple other related or unrelated health conditions, which may have implications for experience and management of the disease; a phenomenon known as multimorbidity. Alectinib price Little research has been done exploring patients' perspectives of COPD and even less is known about impact of comorbidities on the disease. Aim of Study?This qualitative study was conducted to understand the Tryptophan synthase physical, psychological and social impact of a new diagnosis of COPD in the context of multimorbidity. Methods?Participants were diagnosed with COPD during a Sydney-based randomised control trial of case finding and early intervention in COPD. From 254 participants in the trial, 20 participants were identified for the qualitative study using maximum variation sampling based on age, gender, socio-economic status, geographic location and severity of COPD. Data was collected via semi-structured interviews and recorded for transcription purposes. Results?In spite of accepting the diagnosis, most participants had difficulty recognising the significance and incorporating COPD into their lives. Self-management capacity and ability to use healthcare services were challenged by limited understanding of COPD and its implications, complications presented by comorbidities and financial barriers (eg. cost of consulting a specialist). In many cases, the salience of another chronic condition (eg. diabetes) outweighed that of COPD.