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SCC, AC, NET, undiff, sarcoma, and others were all classified as non-UC. Table 2 Distribution and definition of bladder cancer pathologies Period, pathological stage, and pathological grade On the basis of the definitions of the UICC TNM staging system 12 and previous studies corresponding to the American Joint Committee on Cancer staging system 13, we divided the date at diagnosis into: Period 0, 1954�C1992; Period 1, 1993�C2002; and Period 2, 2003�C2010. We divided the pathological stages into: early (0is, 0a, I) and late (II�CIV) stages. We divided the pathological grades into low grade (1, 2) and high grade (3, 4). Observation Pifithrin-�� order period The observation period was a 5-year, right-censored period. Causes of death were divided into overall death and cancer-specific death. Statistical methods The primary aim of the study was to analyze the pathology and survival of patients with bladder cancer, and to detect any sex differences. We used t-tests, ��2 tests, and Fisher's exact tests to compare baseline characteristics between two groups. Proportions PDK4 of non-UC patients were compared using ��2 and Cochran�CMantel�CHaenszel tests stratified by each period. Adjusted odds ratios (ORs) for non-UC were estimated using a multiple logistic regression model adjusted for age and periods. We estimated the 5-year overall survival (5y-OS) and 5-year cancer-specific survival (5y-CSS) using the Kaplan�CMeier method. Cox proportional hazards model adjusted for non-UC, age, and period was used to estimate adjusted hazard ratios (HRs) for overall RGFP966 chemical structure death and cancer-specific death. We also estimated HRs adjusted for non-UC, age, pathological stage, and pathological grade among the patients in Period 2 because TNM classification information was available after 2005. All P-values were two-sided, and P?