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21; number of hospitalizations =0.15; and YES1 annual per-respondent direct costs =$6,088; (see Table 3). The pattern of lost productivity and indirect costs was slightly different. Although no differences were observed with respect to absenteeism, several symptom groups reported significantly higher presenteeism, overall work impairment, activity-related impairment, and higher indirect costs than those without symptoms (see Table 4). As with the health status results, respondents with only poor quality of sleep reported the greatest burden (mean overall work impairment =18.57% and annual per-employee indirect costs =$6,685), followed by respondents with only difficulty falling asleep (mean overall work impairment =18.15% and annual per-employee indirect costs =$6,535). Table 3 Adjusted levels of health care resource use and direct cost differences among those with only one insomnia symptom and those without insomnia Table 4 Adjusted levels of work impairment and indirect cost of those with various insomnia symptoms and those without insomnia Health outcome differences between those with MOTN awakenings and matched controls More specific RNA Synthesis inhibitor comparisons were then made between respondents who reported experiencing MOTN awakenings as their only insomnia symptom and those without insomnia. Postmatch, the difference between groups became negligible (from an effect size perspective) on all key demographic and health history variables (see Table 5). Respondents with only MOTN awakenings were older and more likely to be female, be non-Hispanic white, have annual household incomes $50K or more, be unemployed, and drink alcohol. They also had a greater comorbidity burden (see Table 5). Table 5 Demographic and health history variables pre- and postmatch between those without insomnia and those with only MOTN awakening Respondents with only MOTN awakenings reported worse health status across all summary and domain scores compared with matched controls (all PVolasertib cost (ie, 5-point differences for domain scores). Health utility scores were also significantly worse, to a clinically relevant degree, for respondents with only MOTN awakening compared with matched controls (means =0.77 versus 0.81, respectively; P