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Determination of ACEI or ARB treatment rates was limited to those with an indication based on proteinuria VE-821 solubility dmso (for diabetics, UACR >30 mg/g creatinine, UPCR >150 mg/g creatinine or 24 h urine protein >300 mg; for non-diabetics, UACR >300 mg/g creatinine, UPCR >1000 mg/g or 24 h urine >1.0 g). Outcomes Study outcomes included death, CKD progression to Stage G4 (defined as the first outpatient eGFR value Azastene and Pearson's Chi-square tests, as appropriate. Screening and treatment rates were defined for each group and reported as the number of screens/treatments per 100 person-years. Rates of CKD progression, death and hospitalization for cardiovascular events were determined for each group and expressed as the number of events per 100 person-years. Rates were gender-, age- and baseline eGFR-adjusted in order to compare results across time periods. Adjusted incident rate ratios were determined using Poisson regression, using the 2004�C06 cohort as the reference. All analyses were performed using Stata? 13 (Stata Corp, College Station, TX, USA). Results During Period 1 (1 January 2004�C31 December 2006), Period 2 (1 January 2007�C31 December 2009) and Period 3 (1 January 2010�C31 December 2012), 728, 788 and 956 patients developed CKD, respectively. Pictilisib chemical structure Characteristics of the populations (Table?1) were similar, with two exceptions: GFR was slightly higher at entry over time (49, 49 and 50 mL/min/1.73 m2) and systolic blood pressure was lower (135, 130 and 130 mmHg). Table?1. Characteristics of incident CKD patients at index date, by time period Follow-up time for screening and treatment endpoints, number of events, and crude and adjusted rates are shown in Table?2. During Periods 1, 2 and 3, both unadjusted and adjusted screening rates for proteinuria increased, as did statin treatment rates and nephrology referral rates. ACEI/ARB treatment rates were relatively high throughout all periods, and there was no statistically significant change in ACEI/ARB treatment rates across the time periods analyzed (Figure?1). Table?2. Crude and adjusteda screening and treatment rates among incident CKD patients, by time period Fig.?1. Adjusted rate ratios for screening and treatment among incident CKD patients. Analyses are adjusted for age, gender and baseline eGFR. The y-axis scale for ��Nephrology Referral�� differs from the scale used for the other three figures for .