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By taking together our results, we propose that progesterone would be playing, subchronically, an important role in dopaminergic nigrostriatal pathways in our model of hemiparkinsonism. The effect of progesterone on the expression and activity of 3��-HSOR suggests that ALLO could be one of the possible molecules acutely involved in the previously reported neuroprotective effect. Additionally we propose, as a working hypothesis, that ALLO, through nongenomic GABAA receptor modulation, could regulate local neuroglial circuitries implicated in neuronal death. This might be an alternative cellular mechanism that could be responsible for the delay of the progressive course of the PD. Acknowledgments This work was partly supported by a grant from Quinapyramine the National Research Council of Argentina (CONICET, PIP no. 11220100100126/11) and Selleck MS275 a grant from the University of Mendoza (113/10) to Ricardo Cabrera and Roberto Yunes. Conflict of Interests The authors declare that there is no conflict of interests that would prejudice the impartiality of scientific work.Opponents of plain packaging (PP) in Australia1�C4 and elsewhere5�C8 have claimed that the legislation would create confusion for retailers attempting to locate packs of uniform appearance. This, it was claimed, would result in increases in pack retrieval and overall serving times,9 10 impatience with queuing among customers, and a consequent shift in patronage, sales and profits selleck from small mixed businesses to large discount outlets such as supermarkets.10 11 Surveys of retailers funded by tobacco industry groups reported perceived negative effects among retailers shortly after implementation of the legislation.12 However, studies of retail outlets conducted across Australia over the period of implementation of legislation found no lasting effects on retail serving time13 and a study conducted in the Australian state of Victoria 1?year before (2011) and 1?year after (2013) introduction detected no changes among current smokers in usual place of purchase of tobacco products.14 We aimed to repeat and extend this analysis using a large national data set. We used data from continuous national cross-sectional telephone surveys conducted between 9 April 2012 and 30 March 2014 with about 100 respondents per week aged 18�C69?years, described fully in Wakefield et al15 (this volume).