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There was mild inflammatory cell infiltration, but no evidence of vasculitis. Laboratory data confirmed the absence of vasculitis syndrome or coagulation disorder. The respiratory symptoms gradually improved with oxygen therapy. Figure 1 Histopathological findings of lung tissue section obtained from case 1 visualized by Elastica-Goldner staining. (a) Small pulmonary artery containing MEK inhibitor review old thrombi. The lumen is separated into several channels by recanalization of organized thrombi. (b) ... A 6-year-old girl (case 2) presented with abdominal distention and abdominal pain. A biopsy specimen of the abdominal wall showed primary right adrenal neuroblastoma. Therefore, chemotherapy for neuroblastoma was initiated according to the protocol of the inpatient facility. After the fourth course of chemotherapy, tumorectomy was performed, followed by autologous buy Dacomitinib peripheral blood stem cell transplantation (auto-PBSCT) and high-dose chemotherapy. Soon after completion of the second auto-PBSCT and high-dose chemotherapy, the patient exhibited polypnea and hypoxemia. Chest radiographic examination revealed moderate pleural effusion. As assessed by echocardiography, mean PAP was 40?mmHg. Hypoxia was improved by the administration of diuretics. However, 1 week later, the patient exhibited polypnea, tachycardia, aggravated hypoxemia, and chest pain. Echocardiography showed PH (mean PAP = 70�C75?mmHg) and right ventricular enlargement. Mean PAP decreased to 55?mmHg Furin under nitric oxide (NO) inhalation but increased again after NO withdrawal, despite the administration of sildenafil and epoprostenol. Therefore, lung biopsy was performed for suspected PVOD. The small pulmonary arteries (>150?��m in diameter) showed no intimal proliferation but severe medial thickening (HE classification: I). Pathological findings revealed that small pulmonary arteries and veins (