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People should not act as automatons and deny their feelings about safety and risk however it is sensible to be aware that there may be a ��perception gap�� influencing the way decisions are made. The main problem arises when feelings Palbociclib price are not aligned with facts and the gap is large. Understanding the affect heuristic, personal factors and contextual influences allow us to take a step back, think through the issues more carefully and make sense of seemingly irrational decisions. Slovic argues that analytic reasoning cannot be effective unless it is guided by emotion [27]?and?[28]. Ultimately, rational decision making requires the proper integration of both modes of thought and being careful to always ��mind the gap��. The author has no conflicts of interest relevant to this paper. ""A recent study investigating faecal transplants to eliminate Clostridium difficile infections [1] has elicited further interest regarding the pharmacobiotic potential of the human gastrointestinal microbiome. Probiotic preparations may exhibit significant potential for the treatment of CDAD. Probiotics are defined as living organisms in food and dietary supplements Everolimus order that, upon ingestion, can improve the health of the host beyond their inherent basic nutritional content [2]. The human�Cmicrobial gastrointestinal tract (GIT) interface is an ecosystem that participates in a variety of important roles in human health and disease. Maintaining this ecosystem in a balanced state is a critical requisite for the control of pathogenic bacteria and the associated toxin load produced in the small and large bowel. Pharmacotherapy induced adverse metabolic Cilengitide conditions that ensue can disrupt the GIT homeostasis and contribute towards a dysbiotic burden that increases the risk of CDAD. Clostridium difficile is the most commonly identified causative organism of hospital-acquired diarrhoea, with global infection rates tripling in the past decade [3]. Clinical manifestations can range from mild diarrhoea to toxic megacolon, bowel perforation, septic shock and subsequent death. Research has confirmed that the increased risk for CDAD can be induced by PPI [4]. A recent meta-analysis of 300,000 patients concluded that there was sufficient evidence to demonstrate a strong association between increased rates of CDAD and PPIs, with a 65% increase in infection rates among patients prescribed a PPI [4]. This summarised risk was calculated from the risk estimate of 1.69 with a 95% CI range of between 1.395 and 1.974 (P?
