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Performance at this angle is also marked by increased response variability compared to the upright position, as in the SBT task. The patient's variability is also slightly larger than that of the control subject, whose response pattern matches with previous reports (Bisdorff et?al. 1996). The fitted psychometric curves indicate that patient and control perform generally similar, with slight differences at 90�� tilt. No significant differences between vestibular patients and healthy controls in SBT task Figure?Figure33 depicts the summary statistics (mean and SE) across the six patients and six control subjects, generalizing the observations described in Fig.?Fig.2.2. We subjected bias and response variability values, as obtained selleckchem from the psychometric fits, to a univariate ANOVA with factors angle (0�� and 90��) and group (patients and controls). For the SBT, there was no difference in bias between patients and controls (F(1,5)?=?0.005, P?=?0.95). A significant effect of angle was observed (F(1,5)?=?20.11, P?=?0.006), which can be explained by the small (patients: ?5.7?��?7.0, controls: ?5.3?��?5.6), but systematic, underestimation at 90��. There was no interaction effect between group and angle (F(1,5)?=?0.009, P?=?0.93) Response variability was higher for the DDR1 RED compared to the upright condition (F(1,5)?=?16.11, P?=?0.01), but no effect of group (F(1,5)?=?0.20, P?=?0.68) or interaction between group and angle (F(1,5)?=?0.036, P?=?0.86) was observed. Figure 3 Mean bias and response variability at Temozolomide clinical trial the upright and 90�� roll tilt in both the SBT and SVV task. Error bars denote the standard error across subjects. * indicates P?