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The group data for the initial peak at the four sites are summarized in Fig. 3A. The initial peak CVC averaged 79 �� 3%CVCmax at control sites and 79 �� 2%CVCmax at sites pretreated with substance P. There was no statistical difference between these two sites (P > 0.05). The l-NAME sites (43 �� 3%CVCmax) and substance P plus l-NAME sites (53 �� 3%CVCmax) were significantly reduced compared with both the control Montelukast Sodium and the substance P sites (P www.selleckchem.com/products/epz-6438.html substance P and substance P plus l-NAME sites (P 0.05). However, l-NAME sites (36 �� 4%CVCmax) and substance P plus l-NAME Akt inhibitor sites (56 �� 6%CVCmax) were significantly reduced compared with both control and substance P sites (P 0.05). However, the initial peak and nadir were significantly reduced compared with the secondary plateau (P 0.05). However, the nadir was significantly reduced compared with the initial peak and the secondary plateau (P 0.05). However, the nadir was significantly reduced compared with the initial peak and the secondary plateau (P