Cannabis Study: Full-Spectrum Cannabis Extracts Much more Medically Efficient than CBD Alone
Cannabidiol (CBD) has been the concentrate of many medical cannabis studies, and continues to prove itself as a potent anti-inflammatory drug. What makes CBD even much more desirable for some patients is that it does not cause the psychoactive effects associated with tetrahydrocannabinol (THC).
An very interesting study (Overcoming the Bell-Shaped Dose-Response of Cannabidiol by utilizing Cannabis Extract Enriched in Cannabidiol) was just published out of the Lautenberg Center for General and Tumor Immunology in Jerusalem. The study examines the effectiveness of administering isolated cannabinoid extracts (a CBD-only formula) versus entire plant extracts (which include the full variety of the plant’s cannabinoid content material).
The Hadassah Medical School at the Hebrew University of Jerusalem sought to compare the effectiveness of a completely purified CBD extract versus a full-spectrum extract of cannabis flowers containing large quantities of CBD. The conclusion of the study was that the entire plant extract, which contained a large percentage of CBD but also contained traces of the other cannabinoids, proved far much more efficient than CBD-only solutions in alleviating inflammation and pain sensation. The study demonstrated that a whole plant extract, containing the whole variety of cannabinoids present in raw cannabis, will continue to provide relief for inflammation as the dose is increased. When supplied as an isolated cannabinoid extract, CBD on its personal yielded a bell-curve of effectiveness, which is not desirable for medical remedies looking for effective relief that corresponds with the dosage.
Results Of CBD vs. Full-Spectrum on Inflammation and Pain
The data graphs below compare isolated cannabidiol (CBD) against a full-spectrum cannabis extract (from a CBD-rich strain). In all of the tests, the isolated CBD was ineffective both before and after a certain dosage, whilst the effectiveness of the full-spectrum solution continued to increase as higher doses were administered. The results all indicate that CBD is only effective against swelling and pain at a particular dose, and that cannabis solutions containing a full variety of cannabinoids will continue to offer corresponding effects as the dosage is increased.
Injections: The isolated CBD injection was moderately effective at 5 mg/kg, but became much less effective when the dose was higher. The shape of the graph resembles a bell-curve, indicating that the CBD-only formula lost effectiveness following a particular dose. The results from the cannabis flower extract showed that the synergy between the cannabinoids yielded greater relief as the dosage was increased, which is desirable in medicine.
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