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In conclusion, our study showed that low Ig levels appear to be common in IBD patients. Increase in age, duration of IBD, hypoalbuminemia selleck chemicals llc and the use of immunomodulators are risk factors. The findings of our study may shed some light on the disease course and areas for targeted therapy in IBD patients. Funding This study was partially supported by a research grant from the Crohn��s and Colitis Foundation of America (to B. S.) and the Ed and Joey Story Endowed Chair (to B. S.) Conflict of interest statement: none declared. Supplementary Material Supplementary Data: Click here to view.""Objective: The primary aim of this study was to assess the efficacy of whole-body diffusion-weighted imaging (WB-DWI) in detecting tumour recurrence and metastasis of gastrointestinal cancers by comparison with 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography or computed tomography (18F-FDG-PET/CT). A secondary aim was to evaluate the change of apparent diffusion coefficient (ADC) value between metastases and normal tissues. Methods: Twenty-eight previously confirmed gastrointestinal cancer buy Fulvestrant patients with suspected tumour recurrence or metastasis were recruited. WB-DWI and PET/CT images were evaluated by two radiologists and a nuclear medicine physician. Agreement between WB-DWI and PET/CT for detective efficacy was compared using kappa statistics. Additionally, diagnostic accuracy, sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were also statistically analysed. ADC values between metastatic and normal tissues were compared. Results: There was no statistically significant difference (P?>?0.05) in the overall diagnostic performances of PET/CT (accuracy 98.9%; sensitivity 95.2%; specificity 99.8%; PPV 98.9%; NPV 98.9%) and WB-DWI (accuracy 95.9%; sensitivity 81.7%; specificity 99.1%; PPV 95.0%; NPV 96.1%). WB-DWI showed agreement with PET/CT (��?=?0.877) for detecting recurrence and distant metastases. A statistically significant difference in ADC value was observed between tissues of normal healthy volunteers and metastases in lymph nodes, liver and bones Alizarin (P?