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All reported p-values were two-tailed, and for each analysis p?DDR1 in contrast to VSE bacteraemia, where three-quarters of the isolates were Enterococcus faecalis. There was only one VRE isolate with a vanA genotype, consistent with other epidemiological studies in Australia [7]. The majority of patients with VRE bacteraemia were admitted to the haematology unit (69%), as compared with only 14% of patients with VSE bacteraemia. The incidence of VRE bacteraemia increased during the study period; at the end of the study period, VRE accounted for over one-third of all cases of enterococcal bacteraemia. The results of the univariable and multivariable analysis for VRE bacteraemia are shown in Table?2. In the univariable analysis of VRE bacteraemia, the following factors were most strongly associated with VRE bacteraemia as compared with controls: central venous catheter use; neutropenia; secondary infection; Veliparib VRE colonization; exposure to chemotherapeutic agents with a high risk of mucositis; exposure to antimicrobial therapy in the preceding 30?days, including vancomycin, meropenem, cefepime, ciprofloxacin, piperacillin�Ctazobactam, and metronidazole; intensive-care unit admission; total parenteral nutrition; indwelling urinary catheter; allogeneic bone marrow transplantation; and hypoalbuminaemia. The results of the univariable and multivariable analysis of VSE bacteraemia are shown in Table?3. In the univariable analysis, the following factors were associated with VSE bacteraemia: age; prior gastrointestinal disease; intensive-care unit admission; abdominal surgery; hypoalbuminaemia; secondary infection; indwelling urinary catheter; exposure to piperacillin�Ctazobactam; metronidazole; and Temozolomide chemotherapeutic agents. In the multivariable analysis, four factors were independently associated with VRE bacteraemia: allogenic bone marrow transplantation; neutropenia; central venous catheter use; and hypoalbuminaemia. In the VSE multivariable analysis, four factors were identified as independent predictors of bacteraemia: use of metronidazole in the 30?days prior to bacteraemia; underlying gastrointestinal disease; hypoalbuminaemia; and advancing age. Exposure to meropenem in the 30?days prior to bacteraemia was protective. The mortality rate was significantly higher in the resistant and susceptible analysis than in the control. The 30-day mortality rate was 37.5% in VRE bacteraemia patients as compared with 23.8% and 2.