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All women with a history of GDM who had delivered during 2004 - 2010 in three main hospitals in Zanjan were called to perform laboratory tests and to collect the clinical information. A total of 165 women were called and finally, 110 women with a history of GDM accepted to participate in the study. 3.2. Measurements Anthropometric characteristics including height (using stadiometer), and weight (using Seca scale with the least clothing) were measured. Thereafter, BMI was calculated for all the cases. Waist circumference (WC) was measured at the middle of the subcostal area and the iliac crest with a plastic measure tape. The sedentary blood pressure (BP) was S6 Kinase measured by analog sphygmomanometer after five minutes rest. 3.3. Laboratory Data After at least 12 to 14 hours of fasting, the participants were referred to the predetermined laboratory to draw the blood sample and test for the FBS, OGTT, lipids, and glycosylated hemoglobin (HbA1C). Obviously, the known cases of T2DM were not tested for glucose tolerance. The FBS levels �� 126 mg/dL (�� 6.99 mmol/L) or BS �� 200 mg/dL (�� 11.10 mmol/L) after two hours OGTT established the diagnosis of diabetes. FBS between 100 to 126 mg/dL (5.5-6.99 mmol/L) was defined as Lapatinib ic50 IFG and the blood sugar level of 140 to 199 mg/dL (7.77-11.04 mmol/L) in OGTT was defined as IGT. According to the Iranian National Committee of Obesity criteria, MetS was defined as having any three of the following traits: WC > 95 cm in females; triglyceride (TG) �� 150 mg/dL (> 1.70 mmol/L) or drug consumption for elevated TG levels; high-density lipoprotein (HDL) LY294002 clinical trial or consuming antiglycemic agents (28). 3.4. Statistical Analysis Values were expressed as mean �� standard deviation (SD), and number (percentage), as appropriate. Comparisons were performed by independent-samples t-test for continuous variables and Chi square test for categorical variables. Logistic regression models were used to evaluate the association between GDM and study variables and the dependent variable was a combined variable of IFG, IGT, and DM. Analysis of the data was performed by SPSS 16.0 (SPSS Inc, Chicago, Illinois, the United States). This study was approved by the ethic committee of Zanjan University of Medical Sciences. The written informed consent was obtained from all of the participants. 4. Results In this study, 110 women with a history of GDM with a mean period of 22.8 �� 1.92 months since delivery were included. Thirty-six women (32.7%) had developed T2DM; 11 (10%) IFG (one woman) or IGT (10 women). Moreover, 22 women (20%) had developed with MetS.