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Univariate and multivariate analyses were performed. In the multivariate analyses all variables http://www.selleckchem.com/products/PF-2341066.html were initially included and variables were removed manually based on their estimates (��'s, statistical significance, and changes in explained variance (R2) for the linear regression analyses) using a backward stepwise selection procedure. Since this was a first study regarding the prediction of outcome of joint distraction, a liberal p value (i.e., R428 cell line separate analyses these two variables were included as extra variables in the regression analyses (either using the data from the open prospective cohort study or the data from the randomized controlled trial). Prognostic ability of the models was summarized using the area under the curve (AUC) of the receiver operating characteristic curve (ROC) for the analyses regarding failure. For the analysis regarding pain and disability the explained variance (R2) was used as measure of predictive ability. A univariate and multivariate cox regression analysis was performed with time to failure as dependent variable. Patients UGT1A7 were censored at their last visit. The baseline characteristics gender, age, origin, pain, functional disability, and permission of joint motion during distraction, were used as independent variables. A comparable model building approach was used as in the prediction for 2-year outcome. Data of 111 patients with severe ankle OA treated with joint distraction and participating in either the open prospective study[8] or randomized controlled trial[9] were available. Baseline characteristics of these patients are depicted in Table 1. No significant differences in age, gender and functional disability score at baseline were found between the populations of the two studies. However, pain at baseline was statistically significantly higher in the open prospective study compared to the randomized controlled study (p?