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The PTs to raw meat were positive in 7/14 cases, mostly to beef. The PTs to other offal were positive in 7/8 tested patients, mostly for pork tripe (Table?2). Intradermal tests to Erbitux? can be used to determine a sensitization to ��Gal determinants [9]. All patients tested (n?=?10) showed positive prick or intradermal tests to 5�C500?��g/ml Erbitux? (Table?2). IgE antibodies to pork meat were detected in 11/14 patients (79%), with specific IgE levels ranging from 0.4 to 34.3?kU/l (median, 3.2?kU/l). IgE antibodies to beef were detected in 11/12 patients (92%), with specific www.selleckchem.com/products/Pomalidomide(CC-4047).html IgE levels ranging from 0.15 to 33.5?kU/l (median, 1.8?kU/l) (Table?3). When tested, IgE antibodies to pork serum albumin were slightly detected (5/9; range, 0.1�C0.8?kU/l), but IgE antibodies to beef serum albumin were Selleckchem Nutlin 3a never detected. When tested, no specific IgE antibodies to cat allergens (dander, rFel d 1 or albumin) were detected. IgE reactivity to swine urine proteins was positive in 12/13 patients (range, 0.2�C37.4?kU/l; median, 2.9?kU/l). All cases tested positive for IgE antibodies to ��Gal (median, 14.3?kU/l; range, 0.4�C294?kU/l) (Table?3). A strong correlation was observed between IgE to ��Gal and IgE to swine urine proteins (r?=?0.93; P?Oxymatrine raw beef, 9% for cooked beef, and 2% for raw pork). Cooked pork and chicken contained no ��Gal. Based on the above results, raw pork kidney extract was chosen for preincubation with patient sera to verify its ability to inhibit ��Gal-specific IgE binding by ImmunoCAP?. Raw pork kidney extract inhibited IgE binding to ��Gal in all sera tested (mean, 77%; range, 55�C87%). This finding shows that ��Gal-specific IgE antibodies are able to interact with ��Gal determinants in kidney. The results of this study confirm that allergy to P&BK often induces severe anaphylaxis [2]. All tested patients showed a positive intradermal test to Erbitux? (Table?2). Substantial amounts of ��Gal determinants were observed in kidney, especially pork kidney (Fig.?1). All patients had specific IgE antibodies to ��Gal, and pork kidney inhibited specific IgE binding to ��Gal (Table?3). Taken together, our results suggest that specific IgE antibodies to ��Gal are probably involved in P&BK anaphylaxis.