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The study was reviewed and approved by the ethical commission of H?pital Principal de Dakar. Ex vivo testing of DOX susceptibility was performed as previously described by a 42-h culture test revealed by the Plasmodium lactate dehydrogenase (pLDH) ELISA method [8]. pfmdt and pftetQ copy numbers were estimated by TaqMan real-time PCR as previously described [7]. Data were analysed using R software (version 2.10.1.). Differences in pfmdt and pftetQ copy numbers across phenotypic groups were tested using the Mann�CWhitney U-test. Genotype proportions were compared using the Fisher��s exact test. The Spearman��s rank correlation coefficient (rho) was evaluated between pfmdt Transducin and pftetQ copy numbers. Statistical differences were considered significant when p??25?��M). There was no statistically significant difference between the group with IC50??25?��M in terms of the percentage of isolates with one or more copies of the pftetQ gene (p?0.079, Fisher��s exact test) or pfmdt gene (p?0.066, Fisher��s exact test) (Table?1). No statistically significant difference was found between DOX IC50 medians of isolates with one copy of the pftetQ gene (mean?=?14.41?��M) and more than one copy of the gene (mean?=?20.64?��M) (p?0.16, Mann�CWhitney U-test) (Table?2). Similarly, no statistically significant difference was found between DOX IC50 medians of isolates with one copy of the pfmdt gene (mean?=?14.49?��M) and more GSK126 Selleckchem Staurosporine than one copy of the gene (mean?=?26.04?��M) (p?0.30, Mann�CWhitney U-test) (Table?2). pfmdt and pftetQ copy numbers were significantly correlated (��?=?0.30, CI 95% (0.19�C0.40), Spearman��s test, p?