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All parameters averaged hourly over 24 h in the home cage showed a circadian pattern that was associated with feeding and not the light�Cdark cycle. The MAP, HR and RSNA averaged over 24 h and over 4 weeks were 72 �� 1 mmHg (n= 9), 199 �� 4 beats min?1 and 8.3 �� 1.2 nu (n= 6), respectively (Fig. 2). The MAP and RSNA values averaged over the 12 h when lights were on were similar to values averaged over the 12 selleck inhibitor h of darkness, but HR was 6% higher during the daytime hours than the night-time (P Sulfatase contrast, HR measured in the laboratory (168 �� 4 beats min?1) was 12 �� 3 beats selleck compound min?1 lower than that measured in the home cage over the same period (P Fig. 2). There was no significant effect of time in either the cage or laboratory for any of the variables (Fig. 3). In the home cage, there was a strong correlation between both MAP (r= 0.83) and HR (r= 0.90) and locomotor activity (P