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Affective Problems AZ191 Among female PD patients the anxiety was not only significantly more frequent (85.0% versus 76.5%, p = 0.005), but also more severe (HAM-A score: 16.0 �� 6.9 versus 12.5 �� 6.0, p = 0.001). Although the prevalence of depression was comparable between both sexes (76.2% versus 73.7%, p = 0.386), the severity of depression was worse in women (MADRS score: 14.2 �� 7.6 versus 11.8 �� 8.0, p = 0.003) (Table 2). Similarly, the ��Mood problems�� section of NMSS demonstrated more severe affective problems in the female individuals (15.3 �� 12.3 versus 12.4 �� 14.3, p = 0.016) (Table 2). 3.3.2. Sleep-Related Problems Based on the Hungarian validated threshold values for PDSS-2, 72.7% of females and 63.4% of males reported sleep-related problems (Chi-square test, p = 0.034). Although the female PD patients had more severe nighttime sleep disturbances (measured by the total score of PDSS-2), daytime sleepiness was more common (39.3% versus 26.9%, p = 0.001) and more severe among males (Table 2). 3.3.3. Cardiovascular and Orthostatic Problems Based on the screening item of MDS-UPDRS (1.12 orthostatic symptoms) and the ��Cardiovascular�� section of NMSS, female patients had more often (71.5% versus 62.6%, Chi-square test, p = 0.023) and more severe orthostatic and cardiovascular problems than males (p = 0.004, Table 2). 3.3.4. Sexual find more Problems Male patients had more frequent (31.6% versus 18.1%, p Apoptosis Compound Library manufacturer test) and more severe sexual problems than females (2.9 �� 5.8 versus 1.8 �� 5.2, p = 0.022, Table 2). 3.3.5. Pain Based on the screening item of MDS-UPDRS (1.9 Pain) and the item 27 of NMSS (Pain), women had more frequent (76.5% versus 67.3%, p = 0.014, Chi-square test) and more severe (4.8 �� 3.7 versus 2.1 �� 3.1, p not demonstrate any differences in cognition either by NMSS or specific neurocognitive screening tests (MMSE, MoCA, ACE, and MDRS) (Table 2). 3.3.8. Other NMS Problems Both sexes had similarly frequent and severe urinary, gastrointestinal, and hallucinatory problems. Based on MDS-UPDRS nM-EDL, we could not find any differences in the prevalence and the degree of fatigue, either. 3.4. Impulse Control Disorders in PD Based on the analysis of QUIP, 21.6% of male and 20.0% of female PD patients had any type and any degree of ICD problems (p = 0.850, Table 3). The prevalence and severity of pathological gambling, compulsive eating, and punding were similar in both sexes. However, men had more often hypersexuality (5% versus 0%, p
