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Empirical evidence attests that family drug history and adolescent's own drug use are different risk factors for cognitive functioning (Rose-Jacobs et al., 2011) but, at the same time, they may interact with each other (Tapert DDR1 and Brown, 2000). However, to our knowledge, few studies have investigated the neuropsychological functioning in young adults who are children of drug-addicted parents and who have developed a SUD themselves. The present study aims to investigate the role of early exposure to drugs as a traumatic event, capable of affecting the psychological status of young drug addicts. In particular, it intends to provide preliminary results on neuropsychological functioning and personality profile in young adults (aged 18�C24) who were diagnosed with a severe Substance Use Disorder (to the extent to be referred to residential treatment) and who were exposed to parental alcohol and illegal drug use during their prenatal and postnatal early development. In order to investigate this issue, a group of exposed drug addicts was compared to a group of drug addicts who were not exposed to drugs, and to a group of peers who did not report drug problems. On the basis of previous literature, it can be expected that exposed young drug addicts show greater neuropsychological www.selleckchem.com/products/Methazolastone.html impairments and personality disorders, given the exposure to the toxic effects of drugs and/or to the adverse childrearing environment consequent to parental drug misuse. In sum, parental drug use could be an additional factor that makes the clinical condition of young drug addicts even more severe than the one of the non-exposed counterpart. Materials and methods The present study adopted a descriptive, cross-sectional and correlational perspective for examining the neuropsychological and personality features of a group of young adults with SUDs, offspring of parents with drug problems. Participants Veliparib solubility dmso and procedure Participants with SUDs were recruited from the Therapeutic Community ��Villa Renata�� in Venice, Italy. The following inclusion criteria were adopted: (a) meeting DSM-IV-TR (APA, 2000) criteria for Substance Use Disorder; (b) having spent