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Pulmonary function, lung histopathology, the levels of H2S, TNF-�� and IL-8 in serum, the expression of CSE and phosphorylation of NF-��B p65 in lung tissue were measured. We found that rats in the COPD group had typical impaired pulmonary function and lung histopathology, reduced H2S and elevated TNF-��, IL-8 in serum, decreased CSE expression and increased NF-��B p65 phosphorylation in lung tissue as compared with the control group. Treatment with NaHS prevented the development of COPD and reduced inflammatory markers TNF-��, IL-8 and NF-��B p65 phosphorylation as compared with the COPD group. Whereas inhibition of CSE activity by PPG exacerbated the development of COPD and enhanced inflammatory markers TNF-��, Luminespib IL-8 and NF-��B p65 phosphorylation as compared with the COPD group. In conclusion, our findings indicated that H2S could attenuate the development of COPD, which was possibly mediated by reducing inflammatory cytokines TNF-��, IL-8 via suppressing NF-��B signalling pathway. RHEE CK, YOO KH, LEE JH, PARK YB, HWANG YI, SHIN K-C, KIM JW, LEE SH, YOON HK, JUNG K-S: KOREAN COPD STUDY GROUP (KOCOSS) Department of Internal Medicine, Seoul St Mary's Hospital, Republic of Korea Background:?The GOLD consensus uses symptoms to categorize SERCA patients according to disease severity and guide treatment. COPD Assessment Test (CAT) and modified Medical Research Council (mMRC) are both used to evaluate the symptoms. Purpose:?To examine the discrepancy between CAT and mMRC in patients with COPD. Methods:?Patients were recruited from 50 centers in Korea, as part of the Korean COPD Study Group (KOCOSS) cohort. Results:?Total 882 patients with COPD were eligible for analysis. Age was 71.1?��?7.8 (mean?��?SD) and 90.8% were male. Post bronchodilator FVC, FEV1, and FEV1/FVC were 81.7?��?17.6%, 55.7?��?16.7%, and 49.0?��?12.0%. Mean CAT, mMRC, and SGRQ-c score was 15.6?��?7.8, 1.6?��?1.0, and 35.0?��?19.7. There was significant correlation between CAT and mMRC (R?=?0.49, P?Volasertib nmr 95% CI)) and SGRQ-c 31.3 (Sensitiviity: 0.72, Specificity: 0.74, AUC: 0.79 (0.76�C0.82, 95% CI)) were compatible with mMRC 2. Conclusion:?Although there was correlation between CAT and mMRC, discrepancy between two scores was noted. Further study regarding CAT and mMRC in patients with COPD is needed. RHEE CK, YOON HK Department of Internal Medicine, Seoul St Mary's Hospital, The Catholic University of Korea, Republic of Korea Introduction:?Roflumilast is PDE4 inhibitor, which can decrease exacerbation in patients with COPD. However, adverse effect is a major barrier to use medication.
