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01). The time spent in at least moderate activity (level 3�C4) increased over the year in both groups. Compared with the controls, the increase was more pronounced in the asthma group: 1?h and 40?min per week vs 1?h and 7?min. The mean difference of 33?min per week was statistically significant (P?=?0.01). The increase in activity was most marked during the last 5?months of the study, and the extra gain in activity in the asthma group was seen here (Fig.?2 and Table?2). This was in contrast to the changes in asthma control for which the main improvements were seen the first 5?months of the study (Tables?1 and 2 and Figs?1 and 2). The time spent in vigorous (level 4) activity increased to the same extent in the two groups. At study end, there was no statistically significant flupentixol difference in daily physical activity between the two groups (neither time at rest, light-vigorous, moderate-vigorous or vigorous activity). The improvements in cardiovascular fitness was 2.3?ml?O2/min*kg (7%) in the asthma group and 1.1?ml?O2/min*kg (3%) in the control group (P?OSI 906 it is not known whether it followed a similar time course of change as the changes in activity. The distance run during the exercise challenge test improved to the same extent in the two groups [88?m (asthma) and 67?m (controls)]. Both cardiovascular fitness and running distance during the exercise test were still significantly decreased in the asthma group at study end compared with the controls. In contrast to the changes in the measures of activity and cardiovascular fitness, no statistically significant changes were seen during the year between the two groups in body percent fat, bone mineral density, lean tissue, blood this website pressure heart rate and pubertal development but the children with asthma grew significantly less than their healthy controls (4.8 vs 5.9?cm, P?3 at baseline (23.6?��?65?min/day?=?165.4?min/week) than for patients with an asthma score