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Each sample was tested www.selleckchem.com/products/pci-32765.html in duplicate, and the average is reported in picograms per milliliter. The sensitivity of detection ranged from 15.9 to 3,863 pg/ml for IL-8, 120 to 29,175 pg/ml for ANG-2, 22.6 to 5,500 pg/ml for PAI-1, 44.7 to 10,870 pg/ml for resistin, 3,011 to 731,629 pg/ml for ICAM-1, 141 to 34,174 pg/ml for CRP, and 33.6 to 8,166 pg/ml for HGF. Statistical analysis Statistical comparisons between groups were performed using a ��2 or Fisher's exact test for categorical variables or the non-parametric Mann-Whitney U test for continuous variables. Mean values of adipokines obtained from ELISA assays performed on pre-SCT and post-SCT samples were compared with the non-parametric Mann-Whitney U test for continuous variables. Next, the change in each adipokine at engraftment relative to before the conditioning regimen was initiated was compared using a paired t-test in GVHD and no GVHD groups. RESULTS Demographic characteristics The clinical characteristics of patients are shown in Table I. Forty patients were included in the non-aGVHD (n=20) and aGVHD (n=20) groups consisting of 23 males and 17 females with a median age of 47.5 years (range, 21~64). The patients were TRIB1 diagnosed as AML (n=29) and MDS (n=11), and received transplants from sibling donors (n=16), unrelated donors (n=8), or HLA-mismatched familial donors (n=16). At the time of the transplant, 14 patients (35%) had advanced disease features, which are defined as AML beyond the first remission and high-risk MDS (international prognostic scoring system ��intermediate-2). There were no significant differences between the non-aGVHD and aGVHD groups for median age, sex, pre-SCT disease status, donor type, sources of graft, conditioning intensity, and GVHD prophylaxis. Table I Patients and transplantation characteristics Comparison of the serum levels of each adipokine between pre-SCT and post-SCT (at engraftment) We compared each adipokine level at engraftment with those before the start of the conditioning regimen in all the patients. Resistin levels at engraftment were significantly higher (pwww.selleckchem.com/products/MK-2206.html higher (p=0.071) than those before SCT (Table II). Table II The comparison of apokines between pre- and post-SCT Relationship between the changes of each adipokine level and occurrence of aGVHD Next, we analyzed the change of each adipokine level from pre-SCT to post-SCT in the two groups. In the non-aGVHD group, the pre- and post-SCT HGF levels were 206.6��34.3 and 432.3��108.9 pg/ml, respectively, (p=0.0404, Fig. 1A) and the pre- and post-SCT ANG-2 levels were 3,197.2��328.3 and 4,471.8��568.4 pg/ml, respectively, (p=0.0366, Fig. 1B). On the contrary, in the aGVHD group, the levels of HGF and ANG-2 were not significantly different before and after SCT.