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125 at 6 months (P = 0.006) and ?3.658 at 9 months which was significant (P = 0.002) indicating find more gain in AC height in experimental site ( Graph 5 ). Percentage change in alveolar crest height - Comparative analysis of mean percentage change in AC for both the sites revealed a better result for test site with t value of ?2.921 at 6 months (P = 0.009) and ?3.659 at 9 months, indicating a statistically significant gain in AC height (P = 0.002) ( Graph 4 ). There was a significant reduction in mean plaque scores and GI scores at various intervals during the study. A significant reduction in pocket probing depth was observed in experimental groups when compared to controls. The gain in CALs and GR was non-significant when both groups were compared. However, it was observed that PerioGlas? treated defects showed better results when evaluated radiographically Cystathionine beta synthase to open debridement alone. The percentage fill of defect obtained with PerioGlas? in this study was 46.5% when compared to open debridement alone which was 15.3%. Discussion In the pursuit of quest for the ideal material to support bone repair or regeneration, the deficiencies of autogenous grafts or allogenic bone have led to search for synthetic alloplast. Unfortunately, alloplasts available until recently have yielded inconsistent results and disappointing histological results, often evidenced by encapsulation of the graft particles. Considering only limited studies involving the analysis of PerioGlas? in intrabony defects in South Indian population, the present investigation was designed to clinically and radiographically evaluate particulate bioactive ceramic - PerioGlas? and compare it to the open debridement controls in the treatment of human infrabony vertical osseous defects (three and two walled). In the present study, three walled and two walled infrabony defects were selected as considered in the study of Low et al. 7 A split mouth study design was employed in this study similar to studies of Zamet et al., 4 Ong et al., 26 since; selleck chemicals llc these designs have been used to evaluate a variety of preventive and therapeutic agents particularly in those studies where the procedure or treatment effects are localized. Plaque index scores showed statistically significant reduction at various intervals (P