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8%; OR, 25.51; 95% CI, 7.57 to 85.94; p pRPC1063 clinical trial observation (11.1%; OR, 7.17; 95% CI, 1.61 to 31.05; p=0.010). In Forrest IIb ulcers, DPEB occurred in three of 14 patients after the prophylactic hemostatic procedure (21.4%; OR, 15.65; 95% CI, 3.31 to 73.96; p=0.001) and eight of 66 after observation (12.1%; OR, 7.91; 95% CI, 2.50 to 25.06; p 3). Most cases of DPEB were managed with conservative treatment without performing additional endoscopic hemostasis or surgical intervention. Only four patients required blood Enol transfusion and an additional endoscopic hemostatic procedure. There was no significant difference in the requirement for transfusion between the prophylactic hemostasis and non-hemostasis group (2/89 [2.2%] vs. 2/492 [0.4%], p=0.113) (Fig. 1). DISCUSSION Previous studies reported that the size of the resected tumor was the only significant risk factor for post-ESD bleeding [18,19]. However, there is little clinical data describing the relationship between DPEB VTX2337 and Forrest classification of artificial gastric ulcers during second-look endoscopy. In our study, multivariate analysis determined that a specimen ��40 mm was a significant risk factor for DPEB (OR, 3.03; 95% CI, 1.47 to 6.22; p=0.003). Ulcers with high-risk Forrest classifications such as Ib, IIa, and IIb were another significant risk factor for DPEB (OR, 6.88; 95% CI, 2.81 to 16.88; p